Granulocytes neutrophiles et cancer

Reply to Honjo et al.: Functional relevant expression of Toso on granulocytes.

Chemotactic for Human Granulocytes

A biologically active glutathione adduct of the eicosanoid 5-oxo-eicosatetraenoic acid has been observed as a product formed within the murine peritoneal macrophage. This five-oxo glutathione adduct (FOG 7 ) was structurally characterized using electrospray tandem mass spectrometry as a 1,4 Michael addition product 5-oxo-7-glutathionyl-8,11,14-eicosatrienoic acid. FOG 7 was found to be highly p...

Human Peripheral Blood Granulocytes

A central problem of the current studies on protooncogenes (cellular oncogenes, c-onc) is their role in the control of growth and differentiation of normal cells. The cfos protooncogene has been widely investigated and it has been demonstrated that cfos specific transcripts are induced in proliferating cells (1, 2) and during differentiation (3-6) . In particular, when HL60 (promyelocytic) and ...

Ultrastructure of granulocytes

Histaminase release from human granulocytes

Histaminase (EC-1.4.3.6), one of the two catabolic enzymes for histamine, is contained in human granulocytes. Opsonized zymosan or the calcium ionophore A-23187 induce a dose-dependent release of histaminase from human granulocytes in vitro. Release is completed within 30 min, is temperature dependent, and requires divalent cations. Opsonized zymosan-induced histaminase release was maximal in t...